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Plasmodium vivax in vitro continuous culture: The spoke in the wheel

dc.creatorBermúdez, Maritza
dc.creatorMoreno Pérez, Darwin Andrés
dc.creatorArévalo Pinzón, Gabriela
dc.creatorCurtidor, Hernando
dc.creatorPatarroyo, Manuel A.
dc.date2019-09-13T22:51:19Z
dc.date2019-09-13T22:51:19Z
dc.date2018
dc.date.accessioned2020-04-29T17:45:54Z
dc.date.available2020-04-29T17:45:54Z
dc.identifierBermúdez, M., Moreno-Pérez, D.A., Arévalo-Pinzón, G., Curtidor, H., Patarroyo, M.A. Plasmodium vivax in vitro continuous culture: The spoke in the wheel (2018) Malaria Journal, 17 (1), art. no. 301, .
dc.identifierhttps://malariajournal.biomedcentral.com/track/pdf/10.1186/s12936-018-2456-5
dc.identifier10.1186/s12936-018-2456-5
dc.identifier.urihttp://repositorios.rumbo.edu.co/handle/123456789/150016
dc.descriptionUnderstanding the life cycle of Plasmodium vivax is fundamental for developing strategies aimed at controlling and eliminating this parasitic species. Although advances in omic sciences and high-throughput techniques in recent years have enabled the identification and characterization of proteins which might be participating in P. vivax invasion of target cells, exclusive parasite tropism for invading reticulocytes has become the main obstacle in maintaining a continuous culture for this species. Such advance that would help in defining each parasite protein's function in the complex process of P. vivax invasion, in addition to evaluating new therapeutic agents, is still a dream. Advances related to maintenance, culture medium supplements and the use of different sources of reticulocytes and parasites (strains and isolates) have been made regarding the development of an in vitro culture for P. vivax; however, only some cultures having few replication cycles have been obtained to date, meaning that this parasite's maintenance goes beyond the technical components involved. Although it is still not yet clear which molecular mechanisms P. vivax prefers for invading young CD71+ reticulocytes [early maturation stages (I-II-III)], changes related to membrane proteins remodelling of such cells could form part of the explanation. The most relevant aspects regarding P. vivax in vitro culture and host cell characteristics have been analysed in this review to explain possible reasons why the species' continuous in vitro culture is so difficult to standardize. Some alternatives for P. vivax in vitro culture have also been described.
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.relationMalaria Journal;Vol.17, No.1, Ago 20. 2018 páginas 1-12
dc.relationhttps://repository.udca.edu.co/bitstream/11158/2118/1/s12936-018-2456-5.pdf
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.es
dc.rightshttps://malariajournal.biomedcentral.com/track/pdf/10.1186/s12936-018-2456-5
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución-NoComercial-CompartirIgual
dc.sourcehttps://www.scopus.com/search/form.uri?display=basic
dc.subjectPlasmodium vivax
dc.subjectReticulocitos
dc.subjectMalaria
dc.subjectPlasmodium falciparum
dc.subjectMedios de Cultivo
dc.subjectIn vitro culture
dc.subjectLigand
dc.subjectPlasmodium vivax
dc.subjectReceptor
dc.subjectReticulocyte
dc.titlePlasmodium vivax in vitro continuous culture: The spoke in the wheel
dc.typeArtículo de revista
dc.typeText
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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